Exantema mucocutáneo inducido por Mycoplasma pneumoniae: reporte de caso
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Abstract
Whitin de mycoplasma species, Mycoplasma Pneumoniae is the most predominant and studied pathogen, it causes community-acquired bacterial pneumonia in children over 5 years of age and adolescents, it is easily transmitted through respiratory droplets (flugge) or through direct contact in densely populated environments. Mycoplasma pneumoniae infection is usually self – limiting and mild, however it can cause extrapulmonary infections causing some unusual clinical symptoms when it affects the skin, kidneys, heart, nervous, musculo skeletal, gastrointestinal, and blood stream systems.
Mycoplasma pneumonia-induced mucocutaneus eruption (MIME) is a rare but increasingly described disease characterized by prominent scattered vesicular-bullous or target-shaped eruptions with prodromal symptoms occurring in the preceding 7 to 10 days, and clinical, radiographic or laboratory evidence of an infectious trigger. Diagnosis is made by Polymerase Chain Reaction (PCR) from a throat swab, measurement of specific IgG, IgM, IgA titers in serum, and treatment includes targeted antimicrobial therapy and supportive measures in addition to evaluation and follow-up by Dermatology and Ophthalmology, especially if there is ocular involvement.
The correct identification of Mycoplasma pneumoniae in this case illustrates the importance of a through differential diagnosis and the use of evidence-based treatments
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References
Hu J, Ye Y, Chen X, Xiong L, Xie W, Liu P. Insight into the pathogenic mechanism of Mycoplasma pneumoniae. Curr Microbiol [Internet]. 2023;80(1). Disponible en: http://dx.doi.org/10.1007/s00284-022-03103-0
Ramien ML. Reactive infectious mucocutaneous eruption: Mycoplasma pneumoniae -induced rash and mucositis and other parainfectious eruptions. Clin Exp Dermatol [Internet]. 2021;46(3):420–9. Disponible en: http://dx.doi.org/10.1111/ced.14404
Yan C, Xue G-H, Zhao H-Q, Feng Y-L, Cui J-H, Yuan J. Current status of Mycoplasma pneumoniae infection in China. World J Pediatr [Internet]. 2024;20(1):1–4. Disponible en: http://dx.doi.org/10.1007/s12519-023-00783-x
Vallejo J, Mycoplasma pneumoniae infection in children [Internet]. 2024. Disponible en: https://www.uptodate.com/contents/mycoplasma-pneumoniae-infection-in-children?search=mycoplasma+pneumonia&source=search_result&selectedTitle=2%7E45&usage_type=default&display_rank=2
Chen N, Li M. Case report and literature review: Clinical characteristics of 10 children with Mycoplasma pneumoniae-induced rash and mucositis. Front Pediatr [Internet]. 2022;10. Disponible en: http://dx.doi.org/10.3389/fped.2022.82337
Muñoz-Cruzado Rosete A, Carazo Gallego B, Galindo Zavala R, Martín Pedraz L, Moreno Pérez D. Exantema mucocutáneo inducido por Mycoplasma pneumoniae en pediatría. Acta pediátr Méx [Internet]. 2022;43(5):263. Disponible en: https://www.medigraphic.com/pdfs/actpedmex/apm-2022/apm225a.pdf
Mathes E, Kittler N, Reactive infectious mucocutaneous eruption (RIME). 2024. Disponible en: https://www.uptodate.com/contents/reactive-infectious-mucocutaneous-eruption-rime?search=mycoplasma+pneumonia+eritema+multiforme&source=search_result&selectedTitle=2%7E134&usage_type=default&display_rank=2
Goycochea-Valdivia WA, Alvarez JA, Conejo Fernández AJ, Jiménez ABJ, Cano IM, de Jesús Reinoso Lozano T, et al. Posicionamiento de la Sociedad Española de Infectología Pediátrica sobre el Diagnóstico y Tratamiento de la Infección por Mycoplasma [Internet]. Seipweb.es. [citado el 4 de octubre de 2024]. Disponible en: https://www.seipweb.es/wp-content/uploads/2024/04/PosicionamientoMycopalsma_S.pdf
Guzmán Tena P, Rodríguez Ramos M, Lloret Ruiz C, Vázquez Álvarez ML. Erupción mucocutánea infecciosa reactiva (RIME): expandiendo el espectro de los exantemas mucocutáneos. Actas Dermosifiliogr [Internet]. 2023; Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0001731023009377
Daoud Péreza Z, Ramos Amadora JT, Morillo Gutiérrez B, Muñoz Hiraldo E. Infecciones por virus del herpes simple 1 y 2. https://www.guia-abe.es/temas-clinicos-infecciones-por-virus-del-herpes-simple-1-y-2
Daoud Z., Ramos Amador JT Morillo Gutiérrez B., Muñoz Hiraldo E.. Infecciones por virus Herpes simplex 1 y 2 (v.2/2018). Guía_ABE. Infecciones en Pediatría. Guía rápida para la selección del tratamiento antimicrobiano empírico [en línea]. Disponible en http://www.guia-abe.es/
Lee HY, Adkinson NF Jr, Levy ML, Mockenhaupt M, Corona R, eds. Stevens-Johnson syndrome and toxic epidermal necrolysis: Pathogenesis, clinical manifestations, and diagnosis. In: UpToDate, 2024. Available from: https://www.uptodate.com/contents/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-pathogenesis-clinical-manifestations-and-diagnosis?search=Corticosteroids+in+Stevens-Johnson+Syndrome&source=search_result&selectedTitle=2%7E150&usage_type=default&display_rank=2
Lee HY, Adkinson NF Jr, Levy ML, Mockenhaupt M, Corona R, eds. Stevens-Johnson syndrome and toxic epidermal necrolysis: Management, prognosis, and long-term sequelae. In: UpToDate. 2024. Available from: https://www.uptodate.com/contents/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-management-prognosis-and-long-term-sequelae?search=Corticosteroids+in+Stevens-Johnson+Syndrome&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1
Son MBF, Klein-Gitelman M, Kaplan SL, Seo P, eds. Kawasaki disease: Clinical features and diagnosis. In: UpToDate. 2024. Available from: https://www.uptodate.com/contents/kawasaki-disease-clinical-features-and-diagnosis?search=Kawasaki+Disease&source=search_result&selectedTitle=1%7E120&usage_type=default&display_rank=1
Wetter DA, Callen J, Ofori AO, eds. Erythema multiforme: Pathogenesis, clinical features, and diagnosis. In: UpToDate. 2024. Available from: [URL]. https://www.uptodate.com/contents/erythema-multiforme-pathogenesis-clinical-features-and-diagnosis?search=Erythema+Multiforme&source=search_result&selectedTitle=1%7E91&usage_type=default&display_rank=1
Mathes E, Kittler NW, Levy ML, Corona R, eds. Reactive infectious mucocutaneous eruption (RIME). In: UpToDate, 2024. Available from: https://www.uptodate.com/contents/reactive-infectious-mucocutaneous-eruption-rime?search=Pediatric+Mucocutaneous+Lesions&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1
Green S, et al. Advances in the Treatment of Pediatric Herpes Simplex Virus Infections. J Pediatr Infect Dis. 2023;42(4):412-419.
Vallejo JG, Edwards MS, Blake D, eds. Mycoplasma pneumoniae infection in children. In: UpToDate, 2024. Available from: https://www.uptodate.com/contents/mycoplasma-pneumoniae-infection-in-children?search=Mycoplasma+Pneumoniae+Infection&source=search_result&selectedTitle=1%7E139&usage_type=default&display_rank=1
Wetter DA, Callen J, Ofori AO, eds. Erythema multiforme: Management. In: UpToDate, 2024. Available from: https://www.uptodate.com/contents/erythema-multiforme-management?search=Treatment+of+Pediatric+Erythema+Multiforme&source=search_result&selectedTitle=2%7E91&usage_type=default&display_rank=2
Kaplan SL, Klein-Gitelman M, Seo P, eds. Kawasaki disease: Initial treatment and prognosis. In: UpToDate, 2024. Available from: https://www.uptodate.com/contents/kawasaki-disease-initial-treatment-and-prognosis?search=Kawasaki+Disease&source=search_result&selectedTitle=2%7E120&usage_type=default&display_rank=2
Lee H, Yun KW, Lee HJ, Choi EH. Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children. Expert Rev Anti Infect Ther. 2018 Jan;16(1):23-34. doi: 10.1080/14787210.2018.1414599. Epub 2017 Dec 11. PMID: 29212389. https://pubmed.ncbi.nlm.nih.gov/29212389/
Harris P, et al. Diagnostic Approaches to Pediatric Mucocutaneous Lesions. Pediatr Seki M, Minami T. Kawasaki Disease: Pathology, Risks, and Management. Vasc Health Risk Manag. 2022 Jun 10;18:407-416. doi: 10.2147/VHRM.S291762. PMID: 35711626; PMCID: PMC9196282. https://pubmed.ncbi.nlm.nih.gov/35711626/